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In Vitro Discovery Biology
In Vitro Discovery Biology
In Vitro Discovery Biology
- Cytotoxicity and proliferation assays: 3 D cell culture; cell cycle analysis; microtubule and mitosis test
- Angiogenesis assays: endothelial cell (EC) adhesion, tube formation, aorta ring explant, VEGFR signaling
- Epigenetics assays: Acetyltransferase, DNA Methyltransferase, HDAC, Histone Demethylase, Histone Methyltransferase, Bromodomain, PARP screening, and profiling
- Live cell imaging: adhesion, migration, chemotaxis and wound healing
- Cell-free assays: various kinase, phosphatase, and other enzymatic assays
- Simultaneous multiplex analysis mRNA and proteins
- Reporter gene assays
- In-cell western blot (ICW) based compound screening assays
- Traditional western blot, SDS-PAGE, and 2-D gel
Translational Development
In Vitro Discovery Biology
In Vitro Discovery Biology
- Biomarker validation and measurement using Simple Western
- Characterization of mechanism of action of novel drugs
- Screening of anti-aging agents for cosmetics
- Development of companion diagnostic methods
- Drug combination screening for synergistic studies
- Analysis of post-translational modification of proteins
- Target identification and validation of drug candidates and novel compounds
- Genome-wide gene array, low-density gene array, and real-time RT-PCR
PROTAC Discovery
In Vitro Discovery Biology
Multiplex Live Cell Imaging
- Identify and characterize new, potent, and selective ligands that bind and reprogram E3 ligase substrate specificity with our ligand binding assay.
- Develop, characterize, and validate the warhead end of novel PROTACs.
- Enable sensitive quantitation of PROTAC-mediated degradation of targets for DC50 and Dmax values
- Evaluate the impact of target degraders on efficacy and safety-related translational biomarkers with our automatic western blot, IHC and other platforms.
- Characterize PROTAC selectivity across the proteome and provide a global readout on changes in protein expression using protein microarray such as RPPA.
- Provide on-shelf assays, such as CRBN, BET-VHL binding assay, VHL and CRBN ternary complex formation assay
Multiplex Live Cell Imaging
In vitro Toxicology/Safety Test
Multiplex Live Cell Imaging
- Cell adhesion, migration, chemotaxis and wound healing
3-D In Vitro Models
In vitro Toxicology/Safety Test
In vitro Toxicology/Safety Test
- 3-D anti-psoriatic drug screening
- 3-D cancer cell viability assay
- 3-D spheroid cell invasion assay
- 3-D tumor micro-tissue assay
- 3-D anti-skin aging cosmetic ingredient screening
In vitro Toxicology/Safety Test
In vitro Toxicology/Safety Test
In vitro Toxicology/Safety Test
- Analysis of DNA damage (comet, DNA fiber assay), DNA oxidation; DNA methylation
- Ames test (bacterial reverse mutation, 2 or 5 strains
- Micronucleus test (MNT)
- Mitochondrial toxicity
- CFU assay for hematotoxicity assessment
- Colony-forming cell-fibroblast (CFU-F) assay for mesenchymal toxicity assessment
- Cell-specific cytotoxicity
